Comprehensive genome-wide methylation profiling

Whole Genome Bisulfite Sequencing (WGBS) is an established approach for analysing DNA methylation across the genome at single-base resolution. By using bisulfite conversion, WGBS enables researchers to profile methylation patterns without prior selection of target regions, making it suitable for methylome-wide discovery studies.

WGBS can support the identification of differentially methylated regions, comparison of methylation profiles between samples or study groups, and integration with gene expression or other omics datasets. It is commonly used in epigenomics, developmental biology, cancer research, plant and animal studies, and environmental response research.

Enzyme-based, bisulfite-free genome-wide methylation analysis

Enzyme-based methylation sequencing provides a bisulfite-free approach for genome-wide DNA methylation analysis. Instead of harsh chemical conversion, this workflow uses enzymatic conversion chemistry to distinguish methylated and unmethylated cytosines while helping to preserve DNA integrity and library complexity.

This approach may be useful for studies where DNA quality, input amount or sample value is an important consideration. It supports methylation pattern discovery, differentially methylated region analysis and comparative methylome studies, while offering an alternative genome-wide workflow for researchers looking beyond conventional bisulfite-based methods.

Focused 5mC and genomic analysis from a single sequencing workflow

5-base Sequencing is designed to detect the four standard DNA bases together with 5-methylcytosine (5mC) in a single sequencing workflow. By focusing on 5mC conversion while preserving much of the original genome sequence, it supports methylation profiling alongside variant-aware genomic analysis from the same sample.

This service may be suitable for studies where researchers want to investigate methylation patterns and genetic variation together, including cancer research, rare disease research, biomarker studies and cohort-scale projects. It provides a practical option for projects requiring a focused 5mC signal and variant-aware interpretation.

Comprehensive genome-wide methylation profiling

Whole Genome Bisulfite Sequencing (WGBS) is an established approach for analysing DNA methylation across the genome at single-base resolution. By using bisulfite conversion, WGBS enables researchers to profile methylation patterns without prior selection of target regions, making it suitable for methylome-wide discovery studies.

WGBS can support the identification of differentially methylated regions, comparison of methylation profiles between samples or study groups, and integration with gene expression or other omics datasets. It is commonly used in epigenomics, developmental biology, cancer research, plant and animal studies, and environmental response research.

Enzyme-based, bisulfite-free genome-wide methylation analysis

Enzyme-based methylation sequencing provides a bisulfite-free approach for genome-wide DNA methylation analysis. Instead of harsh chemical conversion, this workflow uses enzymatic conversion chemistry to distinguish methylated and unmethylated cytosines while helping to preserve DNA integrity and library complexity.

This approach may be useful for studies where DNA quality, input amount or sample value is an important consideration. It supports methylation pattern discovery, differentially methylated region analysis and comparative methylome studies, while offering an alternative genome-wide workflow for researchers looking beyond conventional bisulfite-based methods.

Focused 5mC and genomic analysis from a single sequencing workflow

5-base Sequencing is designed to detect the four standard DNA bases together with 5-methylcytosine (5mC) in a single sequencing workflow. By focusing on 5mC conversion while preserving much of the original genome sequence, it supports methylation profiling alongside variant-aware genomic analysis from the same sample.

This service may be suitable for studies where researchers want to investigate methylation patterns and genetic variation together, including cancer research, rare disease research, biomarker studies and cohort-scale projects. It provides a practical option for projects requiring a focused 5mC signal and variant-aware interpretation.