Immunogenomics: Connecting Immune Diversity, Cell State and Response
Immunogenomics is bringing genetics, immune-repertoire sequencing, single-cell technologies and computational biology together to provide a more detailed view of how immune responses vary between individuals, diseases and treatments.
In a new expert article for SEQanswers, powered by Biocompare, Dr Shi-qi An of Novogene Europe shares insights into how immunogenomics is being applied across oncology, infectious disease, vaccine research, autoimmune disease and transplantation.
The article explores where short- and long-read sequencing can provide complementary information, how single-cell sequencing connects immune-cell identity and functional state with paired T- or B-cell receptor sequences, and some of the challenges involved in studying highly polymorphic regions such as HLA and KIR.
It also looks ahead to a more integrated future for immunogenomics, combining single-cell immune profiling with spatial technologies, protein measurements and longitudinal sampling to connect clonotype, function, location and clinical outcome.
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