From Cell Atlases to Action: Turning Single-Cell Data Into Better Drug Discovery Decisions
Cell atlases have transformed how we see cellular diversity. The next challenge is turning that resolution into information that can genuinely influence drug discovery.
Writing for Drug Discovery News, Dr Soni Mohapatra of Novogene Europe looks at how single-cell approaches can help researchers move beyond identifying cell populations to asking which states drive disease, which respond to intervention and which should influence target, model and biomarker decisions.
The feature explores how single-cell profiling can uncover rare or treatment-responsive populations hidden within bulk measurements, while perturbation studies can begin to connect observed cell states with function. It also considers how spatial and multiomics approaches can add tissue context and further biological evidence.
But greater resolution alone is not enough. Study design, biological replication, representative models and clearly defined questions remain essential if single-cell findings are to translate into meaningful discovery decisions.
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